Tzanova, Martina Martin; Moretti, Federica; Grassi, Gabriele; Stein, Paul; Hiorth, Marianne; Abrami, Michela; Grassi, Mario; Di Cagno, Massimiliano Pio (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-25)
The correlation between in vivo and in vitro data is yet not sufficiently optimized to allow a significant reduction and replacement of animal testing in pharmaceutical development. One of the main reasons for this lies in the poor mechanistic understanding and interpretation of the physical mechanisms enabling formulation rely on for deploying the drug. One mechanism that still lacks a proper ...